Complex arseno compounds and process of making same.



PAUL KARRER, 0F FRANKFORT-ON-THE-ll/IAIN,

GERMANY, ASSIGNOR T0 FAEBWERKE VORM. MEISTER LUCIUS & BRTJ'NING, OFH5CHST-0N-THE-MAIN, GERMANY, A COR- PORA'EION OF GERMANY.

COMPLEX ARSENO COMPOUNDS AND PROCESS OF MAKING SAME.

No Drawing.

2b all "whom it may concern:

Be it known that l. Pam. KARRl-IR, lh. l)., chemist, a citizen of theRepublic of Suit zerland, residina at Franlcfort-on-the-Main, Germany,have invented certain new and useful Improvements in Complex ArsenoCompounds and Processes of Making Same, of which the following is aspecification.

l have found that compounds possessing very valuable therapeuticproperties for the treatment of infectious diseases are obtained bygetting together in solution compounds containing the atomic complex:

NE: N

NH1/ m as hexarninoarsenobenzene and derivatives thereof, with 3.3-diamino-4.4 -dioxyarsenobenzene. The solution thus obtained no longercontains the primary products but compounds which are distinguished fromthe hcxaininoarsenobenzene and its derivatives by their solubility incaustic soda lye, and from the diainiuo-dioxyarsenobenzene by theirsolubility in sodium bicarbonate.

The new compounds can be separated from the solution as hydrochloridswhich form These chlorids are and diluted hydroin ether and, as abovementioned, soluble in an excess of sodium bicarbonate and dilutedcaustic soda lye. From the solution of the hydrochloricls the freecompounds are precipitated in the form of yellowish flakes;

It cannot be decided at present what conrei'uiily soluble in waterchlorie acid, insoluble stitution is to be attributed to thesecompounds, but they may be regarded as complex arseno-compounds ofhighermolecular Weight.

The following example will illustrate my invention: V

:2 grams of 3.4.5.3 .4 .o -hexaininoarsenobenzene hydrochlorid and 1.6grams of 3.3-

Patented Feb. 6, iltllill Application filed December 10, 1915. SerialNo. 86,097.

thiamine-4.4-dioxyarsenobenzene hydroclo rid are dissolved together in100 cc. of water and heated to about 80 C. The solution thus obtained isthen poured into 400 cc. of glacial acetic acid. whereupon the newhydrochlorid precipitates in the form of yellowish white flakes. The newcompound is readily soluble in diluted hydrochloric acid, it isdistinguished from hexaininoarsenobenzene by its solubility in causticsoda lye and also from diaminodioxyarsenobenzene by itssolubility insodium bicarbonate.

It is not necessary to heat the aqueous solution to 80 (1., as thereaction also takes place at ordinary temperature if the mixture isallowed to stand for some time.

Having'now described my invention, What I claim is:

1. The process of preparing complex arseno-compounds, which consists ingetting together in solution compounds containing the atomic complex:

As=iks\ -N NHZ/ m, I as hexaminoarsenobenzene and derivatives thereof,with $3.3 -diamiiio-4.4 -dioxyarsenobenzene.

2. The process of preparing complex arseuo-compounds, which consists indissolving in water 13.3 4.4 .55-hexaminoarsenobenzene together with3.i-3-d|amino-4.4-dioXyarsenobenzene, both in the form of theirhydrochlorids, and gently heating this solution.

'3. As new products. the complex arseno compounds, wherein a bodycontaining the atomic complex:

au am N- As=As mn a,

is combined with 3.3 -diainino-44-dioxyar' senobenzene; said compoundsbeing soluble in caustic soda lye and sodium bicarbonate, itshydroehlorid also soluble in Water, almost in the form of theirhydroohlorids also soluinsoluble in alcohol, insoluble in ether. 15) blein Water, insoluble in ether. In testimony whereof I alfix my signature4-. As a new product, a complex arseno in presence of two witnesses. 5compound, wherein hexaminoarsenobenzfene PAUL KARRER' is combined with3.3 -(liamino-4A -dioxyar- 1 Witnesses: senobenzene; being soluble incaustic soda JEAN GRUND, lye and sodium bicarbonate, in the form of CARLGRUND.

